Located in the heart of historic Rochester, the Best Western Fifth Avenue provides a beautiful blend of comfortable home living with the luxuries of a Best Western. The world famous Mayo Medical Center is two blocks away. Our kitchenettes, family rooms and suites make any length of stay seem like a home away from home. Enjoy a relaxing swim in our indoor pool or curl up with a book on a sofa in our beautiful atrium. Take a stroll through historic downtown Rochester and visit the many inviting shops, or follow scenic Highway 52 to visit the largest mall in America. Welcome home to the Best Western Fifth Avenue.